H2O2 vapor is ionized by radio frequency or microwave energy applied in the plasma method. The resulting free radicals (H +, O +, O *, OH +, HOO +) are highly reactive ions; has a strong microbicidal effect. When energy is cut, they turn into water and oxygen and become ineffective. At the last stage of the process, the vacuum is terminated with filtered air. Sterilized medical devices are ready to use, ventilation is not required. It is an effective low temperature sterilization method for heat and moisture sensitive materials. It has no significant corrosive effect apart from some metals. At the end of the process, it turns into water and oxygen, leaves no toxic residue, is safe for the worker and the environment. More than 95% of temperature sensitive sensitive medical devices including robotic and electronic medical devices are compatible with the H2O2 sterilization method. Materials to be sterilized with hydrogen peroxide should not be wet. Since it is incompatible with textiles and cellulose, it is necessary to use a special polypropylene based packaging material for hydrogen peroxide sterilization. In this method, polypropylene material should be used instead of paper in chemical and biological indicators used for sterilization control. The penetration property of hydrogen peroxide is poor. Lumen medical devices have a diameter and length limitation. Company recommendations should be taken regarding lumen diameters and lumen length measurements. H2O2 sterilization has been shown to be effective on prion species that can infect humans and animals.
References: Dezenfeksiyon Antisepsi Sterilizasyon Rehberi 2019
https://www.das.org.tr/kitaplar/DASRehber2019V10.pdf
https://www.sudemed.com/en/product/sterilization-reel-made-of-dupont-tyvek
https://www.sudemed.com/en/product/sterilization-pouch-made-of-dupont-tyvek
https://www.sudemed.com/en/product/class-4-h2o2-plasma-indicator
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